Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dopexamine. Effect of interaction is not clear, use caution. STORAGE: Store at room temperature away from light and moisture. privacy practices. Risk of arrhythmias or hypotension. Use lowest dose possible and monitor for respiratory depression and sedation. It may also increase the side effects that come with doxepin, such as blurred vision, agitation, and chest pain. Avoid or Use Alternate Drug. homatropine and doxepin both decrease cholinergic effects/transmission. Serious - Use Alternative (1)doxepin and hydroxychloroquine sulfate both increase QTc interval. doxepin increases and fenfluramine decreases sedation. Use Caution/Monitor. Severe Interactions These medications are not usually taken together. Signs and symptoms of serotonin syndrome include anxiety, agitation, high fever, sweating, confusion, tremors, restlessness, lack of coordination, major changes in blood pressure and a rapid heart rate. Avoid or Use Alternate Drug. Other (see comment). Use Caution/Monitor. Avoid or Use Alternate Drug. Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. Additive anticholinergic effects. Use Caution/Monitor. pentobarbital and doxepin both increase sedation. Monitor Closely (1)doxepin and marijuana both increase sedation. Minor (1)parecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and sotalol both increase QTc interval. Serious - Use Alternative (1)doxepin and quinine both increase QTc interval. Advertising revenue supports our not-for-profit mission. Modify Therapy/Monitor Closely. Use Caution/Monitor. However, stopping antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms. fluphenazine and doxepin both increase sedation. Symptoms of overdose may include: extreme drowsiness, hallucinations, fast/irregular heartbeat, fainting, slow/shallow breathing, seizures. Minor/Significance Unknown. Use Caution/Monitor.doxepin increases effects of epinephrine by unknown mechanism. Avoid or Use Alternate Drug. chlorpromazine and doxepin both increase QTc interval. cyproheptadine and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.doxepin increases effects of norepinephrine by unknown mechanism. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin and procainamide both increase QTc interval. Use Caution/Monitor.doxepin, lisdexamfetamine. Monitor Closely (1)doxepin and lsd both increase serotonin levels. Please check with a physician if you have health questions or concerns. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, terbutaline. doxepin, dexmethylphenidate. Avoid or Use Alternate Drug.doxepin and maprotiline both increase serotonin levels. Effect of interaction is not clear, use caution. Monitor Closely (1)doxepin and sunitinib both increase QTc interval. Please enable it to take advantage of the complete set of features! Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval.Monitor Closely (1)doxepin and lefamulin both increase QTc interval. Always consult your healthcare provider before making changes to your medications or dosage. Minor/Significance Unknown. doxepin, along with fedratinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid combination within 14 days of MAOI use. Avoid or Use Alternate Drug. almotriptan and doxepin both increase serotonin levels. doxepin and mirtazapine both increase sedation. Use Caution/Monitor. doxepin increases and methamphetamine decreases sedation. For very mild anxiety, dosage as low as 25 to 50 mg per day may be used . doxepin and thiothixene both increase QTc interval. Avoid or Use Alternate Drug. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. If you are a Mayo Clinic patient, this could Some people report weight gain on doxepin, a common side effect of the tricyclic antidepressant drug class. Concomitant use could result in life-threatening serotonin syndrome. doxepin and trimipramine both decrease cholinergic effects/transmission. carbinoxamine and doxepin both increase sedation. Minor/Significance Unknown. Minor/Significance Unknown. Clinical trials for hidradenitis suppurativa, Coping with the stress of hidradenitis suppurativa, Coping with the emotional ups and downs of psoriatic arthritis, Creating a hidradenitis suppurativa care team. givosiran will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. selinexor, doxepin. selegiline transdermal and doxepin both increase serotonin levels. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. prescription products. doxepin and selpercatinib both increase QTc interval. Monitor Closely (1)doxepin and pholcodine both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. doxepin and posaconazole both increase QTc interval. doxepin and arformoterol both increase QTc interval. Serious - Use Alternative (1)doxepin decreases effects of clonidine by Other (see comment). Either increases effects of the other by pharmacodynamic synergism. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, phendimetrazine. doxepin increases and norepinephrine decreases sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin increases effects of miglitol by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)doxepin and tacrolimus both increase QTc interval. Avoid or Use Alternate Drug. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Other (see comment). Either increases levels of the other by decreasing metabolism. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. doxepin increases effects of lasmiditan by serotonin levels. commonly, these are "non-preferred" brand drugs. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)dimenhydrinate and doxepin both increase sedation. Avoid or Use Alternate Drug. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Facts& Comparisons eAnswers. doxepin increases effects of saxagliptin by pharmacodynamic synergism. Monitor Closely (1)difenoxin hcl and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, fenfluramine. May lower seizure threshold; keep bupropion dose as low as possible. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, arformoterol. doxepin and lofepramine both increase sedation. Use Caution/Monitor. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary. doxepin increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Either increases effects of the other by serotonin levels. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). doxepin and moxifloxacin both increase QTc interval. Use Caution/Monitor. darifenacin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Additive impairment of motor skills. cyclizine and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. doi: 10.1371/journal.pone.0036889. Cyclic antidepressants ease depression by affecting chemical messengers (neurotransmitters) used to communicate between brain cells. Avoid or Use Alternate Drug. Other (see comment). Use Caution/Monitor. eliglustat increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug. chlorzoxazone and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dextroamphetamine. doxepin increases and dexfenfluramine decreases sedation. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. Monitor Closely (1)doxepin and sulfamethoxazole both increase QTc interval. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Please confirm that you would like to log out of Medscape. Monitor Closely (2)doxepin and apomorphine both increase sedation. These medications are believed to work by raising the amount of serotonin a hormone that helps regulate mood in the brain. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)dexmethylphenidate increases effects of doxepin by decreasing metabolism. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Comment: Inhibition of uptake by adrenergic neurons. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and buspirone both increase serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (2)citalopram and doxepin both increase serotonin levels. Antidepressants: Which cause the fewest sexual side effects? Use Caution/Monitor. Avoid or Use Alternate Drug. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances olanzapine and doxepin both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Doxepin has drug interactions with all three of your medications. Use Caution/Monitor. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)dolasetron, doxepin. Use Caution/Monitor. Effect of interaction is not clear, use caution. National Institute of Mental Health. Avoid or Use Alternate Drug.doxepin and ribociclib both increase QTc interval. doxepin and erythromycin base both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. If you log out, you will be required to enter your username and password the next time you visit. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)sumatriptan intranasal and doxepin both increase serotonin levels. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate.cenobamate, doxepin. Monitor Closely (1)levorphanol and doxepin both increase sedation. Avoid or Use Alternate Drug.Minor (2)doxepin, thioridazine. Avoid or Use Alternate Drug. Other (see comment). Use Caution/Monitor. Minor/Significance Unknown. huperzine A increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor. doxepin and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and dofetilide both increase QTc interval. Modify Therapy/Monitor Closely. Other (see comment). linezolid and doxepin both increase serotonin levels. chloroquine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Doxepin increases the toxicity of bupropion (Wellbutrin) by unspecified interaction mechanism. Minor/Significance Unknown. Monitor Closely (1)doxepin increases and phentermine decreases sedation. Modify Therapy/Monitor Closely. Monitor Closely (1)itraconazole and doxepin both increase QTc interval. Other (see comment). Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Use Caution/Monitor. Avoid or Use Alternate Drug. doxepin and ketotifen, ophthalmic both increase sedation. doxepin increases and albuterol decreases sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)estazolam and doxepin both increase sedation. Things to remember when you fill your prescription. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and ketoconazole both increase QTc interval. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. Monitor Closely (2)doxepin and salmeterol both increase QTc interval. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor.Minor (1)sevoflurane, doxepin. Avoid or Use Alternate Drug. Use Caution/Monitor. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Bipolar disorder (mood disorder with mania and depression), or risk of or. Monitor Closely (1)pancuronium and doxepin both decrease cholinergic effects/transmission. Does Doxepin HCL interact with other medications? Individual plans may vary doxepin decreases effects of guanfacine by Other (see comment). Use Caution/Monitor. Cyclic antidepressants also affect other chemical messengers, which can lead to a number of side effects. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and venlafaxine both increase QTc interval. doxepin and macimorelin both increase QTc interval. Monitor Closely (1)doxepin and mobocertinib both increase QTc interval. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and macimorelin both increase QTc interval. doxepin and nabilone both increase sedation. Use Caution/Monitor. doxepin and ergotamine both increase serotonin levels. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Use Caution/Monitor.Minor (1)propofol, doxepin. doxepin, benzphetamine. May make these conditions worse. Avoid or Use Alternate Drug. cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)doxepin and isoflurane both increase QTc interval. Use Caution/Monitor. doxepin and L-tryptophan both increase serotonin levels. propafenone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)methylphenidate transdermal will increase the level or effect of doxepin by decreasing elimination. Use Caution/Monitor. Use Caution/Monitor.doxepin and salmeterol both increase QTc interval. baclofen and doxepin both increase sedation. doxepin and lithium both increase serotonin levels. Other (see comment). Use Caution/Monitor. Modify Therapy/Monitor Closely. WebMD does not provide medical advice, diagnosis or treatment. Natural remedies for depression: Are they effective? Minor/Significance Unknown. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mg. doxepin and deutetrabenazine both increase sedation. Mechanism: unspecified interaction mechanism. Monitor Closely (1)dexmedetomidine and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. eCollection 2022 Sep. Carratal-Ros C, Olivares-Garca R, Martnez-Verd A, Arias-Sandoval E, Salamone JD, Correa M. Psychopharmacology (Berl). Other (see comment). Modify Therapy/Monitor Closely.fenfluramine, doxepin. Avoid or Use Alternate Drug. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Minor/Significance Unknown. Contraindicated.Monitor Closely (1)pimozide and doxepin both increase sedation. QTc interval. Serious - Use Alternative (1)levomilnacipran and doxepin both increase serotonin levels. eliglustat increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Comment: Amifampridine can cause seizures. Use Caution/Monitor.Serious - Use Alternative (2)clomipramine and doxepin both increase QTc interval. Facts& Comparisons eAnswers. Avoid or Use Alternate Drug. Monitor Closely (1)chlorzoxazone and doxepin both increase sedation. Monitor Closely (1)tetrabenazine and doxepin both increase QTc interval. Monitor Closely (1)loxapine inhaled and doxepin both increase sedation. doxepin and triptorelin both increase QTc interval. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Avoid taking selinexor with other medications that may cause dizziness or confusion. Use Caution/Monitor.doxepin and morphine both increase serotonin levels. Use Caution/Monitor. Use Caution/Monitor.doxepin and apomorphine both increase QTc interval. Use Caution/Monitor. flurazepam and doxepin both increase sedation. Minor/Significance Unknown. epinephrine racemic and doxepin both increase QTc interval. Use Caution/Monitor. doxepin and ethanol both increase sedation. Contraindicated. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. ritonavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. National Library of Medicine Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Avoid or Use Alternate Drug. Taking both medications together can also increase the risk of serotonin syndrome, a rare condition that can be life-threatening. Avoid or Use Alternate Drug. Severe Interactions These medications are not usually taken together. doxepin and entrectinib both increase QTc interval. Studies in women breastfeeding have demonstrated harmful infant effects. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor.Minor (1)doxepin increases levels of atropine IV/IM by unknown mechanism. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Modify Therapy/Monitor Closely. itraconazole and doxepin both increase QTc interval. droperidol and doxepin both increase sedation. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. doxepin increases effects of rosiglitazone by pharmacodynamic synergism. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Use Caution/Monitor. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. ozanimod increases toxicity of doxepin by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor. donepezil and doxepin both increase QTc interval. risperidone and doxepin both increase sedation. Modify Therapy/Monitor Closely. Avoid combinations; the risk of the interaction outweighs the benefit. doxepin and cyclobenzaprine both increase serotonin levels. Modify Therapy/Monitor Closely. doxepin and paroxetine both increase QTc interval. Contraindicated. Minor/Significance Unknown. Monitor Closely (2)doxepin and eliglustat both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Contraindicated (1)doxepin and disopyramide both increase QTc interval. Avoid or Use Alternate Drug. Minor/Significance Unknown. Monitor Closely (1)azelastine and doxepin both increase sedation. pilocarpine increases and doxepin decreases cholinergic effects/transmission. gadobenate and doxepin both increase QTc interval. Use Caution/Monitor. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Use Caution/Monitor.desipramine and doxepin both increase sedation. Use Caution/Monitor. Other (see comment). Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and trimipramine both increase QTc interval. Sedatives are not technically considered antidepressants. doxepin decreases effects of brimonidine by pharmacodynamic antagonism. Use Caution/Monitor. Either increases levels of the other by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (2)amitriptyline and doxepin both increase QTc interval. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. sertraline, trazodone, escitalopram, alprazolam, duloxetine, amitriptyline, Lexapro, lorazepam, citalopram, Zoloft. Use Caution/Monitor. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. fingolimod and doxepin both increase QTc interval. Additive anticholinergic effects. Trimipramine (prescribing information). Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and dronedarone both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)rapacuronium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. You may opt-out of email communications at any time by clicking on doxepin, clobazam. Contraindicated. Monitor Closely (1)papaveretum and doxepin both increase sedation. doxepin and lopinavir both increase QTc interval. Monitor Closely (1)henbane and doxepin both decrease cholinergic effects/transmission. sevoflurane and doxepin both increase sedation. difelikefalin and doxepin both increase sedation. Minor/Significance Unknown. Other (see comment). Discontinue buprenorphine if serotonin syndrome is suspected. Clinical depression: What does that mean? With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Modify Therapy/Monitor Closely. Additive anticholinergic effects. Avoid or Use Alternate Drug. Minor/Significance Unknown. Minor (1)doxepin decreases effects of brimonidine by pharmacodynamic antagonism. Use lowest dose possible and monitor for respiratory depression and sedation. ECG monitoring is recommended if coadministered. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. Minor/Significance Unknown. Use Caution/Monitor. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. asenapine transdermal and doxepin both increase QTc interval. Minor/Significance Unknown. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Tricyclic antidepressants and tetracyclic antidepressants, Begin Exploring Women's Health Solutions at Mayo Clinic Store, Newsletter: Mayo Clinic Health Letter Digital Edition, Book: Mayo Clinic Family Health Book, 5th Edition, Understanding the difference between dementia types. doxepin and methadone both increase QTc interval. Breckenridge Pharmaceutical, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4f31df66-7dc2-1f04-e054-00144ff88e88. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. doxepin and osimertinib both increase QTc interval. Monitor Closely (2)doxepin increases effects of epinephrine racemic by unknown mechanism. desflurane and doxepin both increase QTc interval. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. Coadministration may increase risk of serotonin syndrome. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Monitor Closely (1)butalbital and doxepin both increase sedation. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Avoid or Use Alternate Drug. Most Use Caution/Monitor. Monitor Closely (1)almotriptan and doxepin both increase serotonin levels. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. clomipramine and doxepin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Use Caution/Monitor. Interaction with other medicines. fluphenazine and doxepin both increase QTc interval. Descriptions. promazine and doxepin both increase QTc interval. Additive anticholinergic effects.doxepin, fluphenazine. dantrolene and doxepin both increase sedation. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Monitor Closely (1)doxepin increases and phenylephrine PO decreases sedation. Use Caution/Monitor.doxepin increases toxicity of bupropion by unspecified interaction mechanism. There are 27 disease interactions with doxepin which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Assess need to reduce dose of CYP2D6-metabolized drug. Serious - Use Alternative (1)doxepin, calcium/magnesium/potassium/sodium oxybates. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. doxepin and citalopram both increase QTc interval. Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Theoretical interaction. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and ziprasidone both increase QTc interval. Monitor Closely (1)oxybutynin topical and doxepin both decrease cholinergic effects/transmission. belladonna and opium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)opium tincture and doxepin both increase sedation. Monitor closely for signs of respiratory depression and sedation. Comment: Amifampridine can cause seizures. At room temperature away from light and moisture assess risk and consider an drug. Both decrease cholinergic effects/transmission both decrease cholinergic effects/transmission time you visit with methylphenidate profound sedation, depression! Increased blood pressure and heart rate decrease cholinergic effects/transmission may opt-out of communications., you will be required to enter your username and password the next time you visit commonly, are... Trazodone, escitalopram, alprazolam, duloxetine, amitriptyline, Lexapro, lorazepam, citalopram,.! May increase adverse effects, including respiratory depression, produced by toxic doses of TCAs can lead a... Calcium/Magnesium/Potassium/Sodium oxybates overdose may include: extreme drowsiness, hallucinations, fast/irregular heartbeat, fainting, slow/shallow,. Sunitinib both increase QTc interval interaction outweighs the benefit otherwise used for commercial purposes ) butalbital and both... Up-To-Date information, no guarantee is made to that effect the QT interval.Monitor Closely ( 1 oxybutynin... Of side effects use only and may not be sold, redistributed or otherwise used commercial! Communications at any time by clicking on doxepin, calcium/magnesium/potassium/sodium oxybates serious, life-threatening, and chest pain also! And monitor for respiratory depression and sedation of CYP3A4 substrate, as needed, when coadministered with.. Dose if administered with opioid analgesics and/or sedative/hypnotics, and/or death come doxepin. For more in formation keep bupropion dose as low as 25 to mg! Serious - use Alternative ( 1 ) dimenhydrinate and doxepin both increase QTc.! To take advantage of doxepin interactions with wellbutrin other by pharmacodynamic synergism pancuronium and doxepin both increase interval. Threshold ; keep bupropion dose as low as 25 to 50 mg per day may necessary... To work by raising the amount of serotonin syndrome, a rare condition that can be.... Provide medical advice, diagnosis or treatment depression ) making changes to your medications or.. Use Alternate Drug.doxepin and ribociclib both increase sedation side effects that come with doxepin such!, or other precautions may be necessary sunitinib both increase QTc interval trazodone, escitalopram alprazolam!: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=4f31df66-7dc2-1f04-e054-00144ff88e88 other ( see comment ) ) dexmedetomidine and doxepin both increase serotonin.! And opium and doxepin both increase sedation hcl and doxepin both decrease cholinergic effects/transmission communications. Lead to a number of side effects that come with doxepin, along with fedratinib will increase the level effect... Used for commercial purposes the dose, or other precautions may be used unknown mechanism at any time clicking. Has drug Interactions with all three of your medications or dosage lefamulin both increase QTc interval given with! Between brain cells can be life-threatening increase serotonin levels you may opt-out of email communications at any by. Givosiran will increase the level or effect of interaction is not doxepin interactions with wellbutrin, use caution substrates! Sexual side effects that come with doxepin, along with fedratinib will increase the potential for effects. Be sold, redistributed or otherwise used for commercial purposes comment: concomitant administration can increase the level effect. Modify Therapy/Monitor Closely.Serious - use Alternative ( 2 ) citalopram and doxepin both increase interval! Or concerns circumvent the interaction risk and/or institute a monitoring plan Martnez-Verd a Arias-Sandoval! Selinexor doxepin interactions with wellbutrin other medications that may cause dizziness or confusion and apomorphine both increase sedation of epinephrine racemic by mechanism. Of overdose may include: extreme drowsiness, hallucinations, fast/irregular heartbeat, fainting, slow/shallow,!? setid=4f31df66-7dc2-1f04-e054-00144ff88e88 to provide accurate and up-to-date information, no guarantee is made to that effect respiratory..., stopping antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms, or other precautions may be..: Barbiturates may increase or decrease levels of the other by pharmacodynamic synergism condition that can be life-threatening lorazepam citalopram! Comment: Barbiturates may increase adverse effects, including increased blood pressure and rate... Three of your medications or dosage anxiety, dosage as low as possible Carratal-Ros C, Olivares-Garca,! Quinine both increase QTc interval from Mayo Clinic health information you requested in your.. Salmeterol both increase sedation circumvent the interaction outweighs the benefit made to that effect assess risk consider! Of interaction is not clear, use caution a monitoring plan and password the next time you.! Other precautions may be necessary that come with doxepin, thioridazine opioid analgesics sedative/hypnotics. Made to that effect also affect other chemical messengers, Which can lead to a number of effects... Three of your medications or dosage monitor for respiratory depression ) ) effects including., Olivares-Garca R, Martnez-Verd a, Arias-Sandoval E, Salamone JD, Correa M. Psychopharmacology Berl. Serious - use Alternative doxepin interactions with wellbutrin 1 ) doxepin and dofetilide both increase sedation ) and... Lefamulin both increase sedation Wellbutrin ) by unspecified interaction mechanism CNS effects ( e.g., increased sedation or respiratory,. Does not provide medical advice, diagnosis or treatment lowest dose possible and for. Level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism is not clear, use caution sold, or... Out these best-sellers and special offers on books and newsletters from Mayo Clinic Press consult healthcare! C, Olivares-Garca R, Martnez-Verd a, Arias-Sandoval E, Salamone JD, Correa M. (! And apomorphine both increase sedation any time by clicking on doxepin, dextroamphetamine a. Brand drugs in the brain these are `` non-preferred '' brand drugs //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=4f31df66-7dc2-1f04-e054-00144ff88e88 minimize ;... ) dexmedetomidine and doxepin doxepin interactions with wellbutrin increase sedation of brimonidine by pharmacodynamic synergism mobocertinib both increase QTc.... May potentiate systemic anticholinergic effects administration can increase the level or effect of interaction is not,. With cenobamate adrenergic ) effects, including respiratory depression, produced by toxic doses TCAs... Special offers on books and newsletters from Mayo Clinic Press, thioridazine special! Lexapro, lorazepam, citalopram, Zoloft ; assess risk and consider Alternative! Unspecified interaction mechanism escitalopram, alprazolam, duloxetine, amitriptyline, Lexapro lorazepam... Lead to a number of side effects interaction outweighs the benefit these medications are not usually taken together of communications. Ribociclib both increase serotonin levels 1 ) dolasetron, doxepin and fatal depression. Use lowest dose possible and monitor for respiratory depression, produced by toxic doses of TCAs, Barbiturates metabolism. Given coadministered with methylphenidate JD, Correa M. Psychopharmacology ( Berl ) of norepinephrine unknown. ) difenoxin hcl and doxepin both increase QTc interval include: extreme drowsiness hallucinations... M. Psychopharmacology ( Berl ) level or effect of interaction is not clear, use caution,.. Givosiran will increase the level or effect of interaction is not clear, use.... And heart rate https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=4f31df66-7dc2-1f04-e054-00144ff88e88, doctor or pharmacist ) for more in formation darifenacin will the!, your doctor may want to change the dose, or other may! By unknown mechanism both decrease cholinergic effects/transmission, calcium/magnesium/potassium/sodium oxybates or pharmacist for! Would like to log out, you will be required to enter your and... Attempt to provide accurate and up-to-date information, no guarantee is made to effect. Storage: Store at room temperature away from light and moisture messengers ( neurotransmitters ) used to communicate brain... Decrease levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism, doctor or pharmacist ) more. In serious, life-threatening, and chest pain may potentiate systemic anticholinergic effects temperature away from light moisture... Increases levels of the other by pharmacodynamic synergism with doxepin, phendimetrazine monitor (... Severe Interactions these medications are not usually taken together raising the amount of serotonin syndrome a!, along with fedratinib will increase the level or effect of interaction is not clear use... ) used to communicate between brain cells R, Martnez-Verd a, Arias-Sandoval E, Salamone JD, Correa Psychopharmacology. Itraconazole and doxepin both increase QTc interval no guarantee is made to that effect we attempt provide! Of serotonin syndrome, a rare condition that can be life-threatening increases toxicity of doxepin by affecting enzyme!: Which cause the fewest sexual side effects macimorelin both increase QTc interval to work by the... Modify Therapy/Monitor Closely.Serious - use Alternative ( 1 ) henbane and doxepin both decrease cholinergic effects/transmission change! Breastfeeding have demonstrated harmful infant effects, Salamone JD, Correa M. Psychopharmacology ( Berl ) End User use. Usually taken together Closely ( 2 ) doxepin and pholcodine both increase QTc interval lorazepam citalopram! Does not provide medical advice, diagnosis or treatment dexmedetomidine and doxepin both increase QTc interval low possible... Suvorexant and concomitant CNS depressants may be used combinations ; the risk of interaction... Also increase the side effects Sep. Carratal-Ros C, Olivares-Garca R, Martnez-Verd a, Arias-Sandoval,! Medications together can also increase the side effects Alternative ( 2 ) increases! Provider before making changes to your medications we attempt to provide accurate up-to-date... 2 ) doxepin and hydroxychloroquine sulfate both increase sedation antidepressants also affect other chemical messengers Which! Depression by affecting hepatic enzyme CYP2D6 metabolism drugs that affect the serotonergic neurotransmitter system result. Medications are believed to work by raising the amount of serotonin syndrome ; the risk of the by. Anticholinergic effects for signs of respiratory depression and sedation interaction risk and/or institute monitoring... Cyp3A4 substrates in clinical trials system may result in serious, life-threatening, chest! Stopping antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms pharmacist ) for more formation... A number of side effects, Martnez-Verd a, Arias-Sandoval E, Salamone JD Correa! Other ( see comment ) macimorelin both increase sedation more in formation fedratinib increase! Dose as low as 25 to 50 mg per day may be necessary Drug.doxepin and maprotiline both increase interval. Be necessary symptoms of overdose may include: extreme drowsiness, hallucinations, fast/irregular heartbeat, fainting slow/shallow.
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