Biosplice Therapeutics is a clinical-stage biotechnology company focused on developing first-in-class, small-molecule therapeutics based on the pioneering science of alternative pre-mRNA splicing. In addition to the three companies above, Salt Lake City-based Recursion Pharmaceuticals, Netherlands-based LAVA Therapeutics, New Jersey-based Certara, and San Diego-based Evofem are all lining up to begin trading as a public company. Sands Capital Ventures and Verition Fund Management are the most recent investors. Early market entry is fundamental, and manufacturers must plan strategically to consider how digital therapeutics (DTx) are best incorporated into the launch and go-to-market strategy. Finances from the IPO, as well as the cash from the Series B, will be used to develop treatments for nucleotide repeat expansion disorders, including its lead program in Friedreich ataxia, which is expected to enter clinical development in the first half of 2022. Merck has been looking to get its blockbuster drug Keytruda into earlier lines of treatment, and one of its latest trial results has the anti-PD-1 antibody moving firmly in that direction. Hes even a co-founder at Verve, which is carrying the banner for base editing. Biosplices target class governs the selection of tissue-specific mRNA splice sites, making them attractive, druggable targets within the cellular command and control center. Gerostate Alpha is a Y Combinator-backed anti-aging spinout from the Buck Institute. Among other company's drugs are Cirtuvivint (for treatment of oncological diseases, phase 1) and Dalosirvat (anti-hair loss drug, phase 2/3). Biosplice Therapeutics, Inc. ClinicalTrials.gov Identifier: NCT03742518 Other Study ID Numbers: SM04554-AGA-05 : First Posted: November 15, 2018 Key Record Dates: Last Update Posted: December 28, 2021 Last Verified: December 2021 Layout table for additional information . We are particularly excited by lorecivivint, which has the potential to be a first-in-class medicine that could confer both symptomatic and disease-modifying benefits to hundreds of millions of osteoarthritis sufferers worldwide.. In January, Ikena announced IK-930, a TEAD inhibitor targeting the Hippo signaling pathway, has entered IND-enabling studies. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services. Here are similar public companies: HealthStream (NAS: HSTM), Doximity (NYS: DOCS), Zymergen (NAS: ZY), Sight Sciences (NAS: SGHT). Biosplice Therapeutics has produced fresh biological insights and unique chemical equity that delivers therapeutic modulation of alternative splicing by targeting the CLK/DYRK family kinases. 308 followers 310 connections. After Novartis acquired AveXis, executives from the leading gene therapy biotech shuffled off to form new startups looking to repeat their Zolgensma story for other diseases. Measurement of overall survival, the other primary endpoint, remains ongoing. Bioscience & Technology Business CenterThe University of KansasLawrence, Kansas. Investing in private companies may be considered highly speculative and involves a high degree of risk, including the risk of substantial loss of investment. Learn more about how Forge might help you buy pre-IPO shares or sell pre-IPO shares. SAN DIEGO, April 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. (Biosplice), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing for major diseases, announced today it has closed $120 million in equity financing from a new biotechnology investment syndicate. His research on drug delivery, which led him to co-found Moderna in 2010, went on to prove critical in developing the companys Covid-19 vaccine. Biosplice Therapeutics is attempting to clear its late-stage knee osteoarthritis treatment after other biopharmas have reached snags in the past year, and it now has $140 million worth of confidenc So they plan to test it in patients with mismatch repair mutations, so the tumors are already making mutations. Please note this link is one-time use only and is valid for only 24 hours. About BiospliceBiosplice is developing first-in-class, small-molecule therapeutics based on pioneering science of alternative pre-mRNA splicing. Alternative splicing is an essential biological mechanism that regulates the diversification of proteins in a cell, which, in turn, determines cell type and function. Then for Roche, they have a drug that's targeting WRN [a gene that encodes a DNA repair protein]; it's a helicase. Tags Biosplice Therapeutics oncology clinical trials cirtuvivint alternative splicing CLK/DYRK pre-mRNA splicing NSCLC CRC CRPC. They have a separate drug for autoimmune disease and for oncology that are partnered with Bristol Myers Squibb. Conversely, dysregulated alternative splicing can be a root cause of developmental disorders, tissue degeneration and cancer. Unlock this story instantly and join 161,500+ biopharma pros reading Endpoints daily and it's free. In addition, we expect to realize the tremendous potential of our oncology program, as well as neurology and other areas of significant unmet need., Joy Ghosh, PhD, of Eventide Asset Management, added, Biosplices alternative splicing platform has enormous potential to address critical needs in osteoarthritis, oncology and neurology, among others. Focused on tissue-level regeneration to treat aging related diseases, Biosplice states its mission is to "restore human health via novel therapies that use alternative splicing The company asserts that medicines that can harness this process will help cure musculoskeletal, ummune and oncological disorders. Learn more about Biosplice Therapeutics stock. | After reaching a $12 billion valuation in 2018 . Your use of the Website and your reliance on any information on the Website is solely at your own risk. If the company doesn't have early-stage data, maybe isn't in late-stage, so you can, as an investor, look at the early-stage data. Learn More. Learn more at https://www.biosplice.com, Corporate Contact:Erich HorsleyBiosplice Therapeutics, Inc.erich.horsley@biosplice.com858-365-0200, GLOBAL MARKETS-US stocks muted, Treasuries dip as inflation worries linger, Stock market news today: Stocks waver after key manufacturing data, Salesforce set to report earnings Thursday, Goldman Sachs tries to reset firm culture after three 'unusual' years, Shipping companies reach $97M California oil spill agreement. A biotech born out of the work of Stanford CAR-T leader Crystal Mackall is publicly unveiling its $200 million Series A Wednesday, after already going through a Phase I clinical trial, rebranding and setting up plans for a potential registrational study. The company focuses on potential treatments for several diseases; its osteoarthritis program is its most advanced. Still, he faced a string of rejected grants and skepticism. With their platform's origins in small molecule-based Wnt pathway modulation, they develop therapeutics to address a range of degenerative diseases, regenerative medicine, and oncology. Persons. Digital therapeutics support increased access to safe and effective therapies, providing an untapped opportunity for biopharmaceutical companies to maximize the value of medicinal assets and drive differentiation Samumed adopted a fresh operating philosophy from the. Other disorders the company will target with its GeneTac platform will include myotonic dystrophy type-1, and other indications that have yet to be publicly announced. After about two or three hundred failures, Langers team had already proved the idea could work in a 1976 paper published in Nature. Our Private Market Specialists are available to answer any questions you might have and can help connect you with a buyer from our network of 125,000 accredited investors and institutions. Other assets in development include a lead optimization-stage ERK5 targeting the KRAS signaling pathway dubbed IK-175; an AHR antagonist known as IK-175; a kynurenine-degrading enzyme known as IK-412; and IK-007, an EP4 receptor antagonist. In September 2020, Sorrento Therapeutics released positive Phase 1b trial data (clinicaltrials.gov NCT03542838) of resiniferatoxin (RTX) in the reduction of OsteoArthritis (OA) knee pain. But there was a new treatment he could try: a targeted radiotherapy called Pluvicto if he could get it in time. Systems Engineer. Design said it expects to raise approximately $240 million from the IPO, a little bit higher than the $228 million the company previously anticipated. By registering, you agree to Forges Terms of Use. *Average returns of all recommendations since inception. As much promise as I want to give to Sana's pipeline, I have a hard time getting to the $3.4 billion valuation. Biosplices drugs in clinical development include lorecivivint for osteoarthritis (in Phase 3), cirtuvivint for numerous cancers, and a broad pipeline that ranges from Alzheimers disease to other degenerative conditions. The stock price for Biosplice Therapeutics will be known as it becomes public. Biosplice Therapeutics, Inc. (formerly Samumed, LLC) is a private biopharmaceutical company based in San Diego, California.It was founded in 2008 by Osman Kibar.. Samumed's products in development target novel components of the Wnt signaling pathway. The company asserts that medicines that can harness this process will help cure musculoskeletal, ummune and oncological disorders. We are particularly excited by lorecivivint, which has the potential to be a first-in-class medicine that could confer both symptomatic and disease-modifying benefits to hundreds of millions of osteoarthritis sufferers worldwide.. Biosplice Therapeutics Inc - Company Profile and News - Bloomberg Markets Subscribe Live Now Bloomberg TV+ Bloomberg Surveillance: Early Edition Bloomberg Surveillance: Early Edition with Anna. By accessing this site and any pages thereof, you agree to be bound by our Terms of Use.EquityZen and logo are trademarks of EquityZen Inc. Other trademarks are property of their respective owners. 2023 EquityZen Inc. All rights reserved. They say everything is great, no problems. Biosplice Therapeutics was founded in 2021. SAN DIEGO, Jan. 27, 2022 /PRNewswire/ -- Biosplice Therapeutics, Inc., a clinical-stage biotechnology company pioneering therapeutics based on CLK/DYRK kinase modulation for major diseases,. Stemming from foundational discoveries in Wnt pathway. 2/27/2023. Initial public offerings (IPOs) can provide opportunities for investors to jump aboard promising stocks early. About BiospliceBiosplice is developing first-in-class, small-molecule therapeutics based on pioneering science of alternative pre-mRNA splicing. Biosplice Therapeutics uses 8 technology products and services including HTML5 , Google Analytics , and Vimeo, according to G2 Stack. The company's claim to fame is that it's amassed a. EquityZen Securities LLC (EquityZen Securities) is a subsidiary of EquityZen Inc. EquityZen Securities is a broker/dealer registered with the Securities Exchange Commission and is a FINRA/SIPC member firm. That level of fanfare was nowhere to be found on Thursday, when the company added another $120 million to its coffers and quietly changed its name to Biosplice Therapeutics. In 2020, the firm delivered a less-than-stellar performance in its first major study, laid off some staff, and incurred a drop in its market valuation. Contacts. Design said it expects to raise approximately $240 million from the IPO, a little bit higher than the $228 million the company previously anticipated. Youre reading a free article with opinions that may differ from The Motley Fools Premium Investing Services. April 15, 2021 10:55 ET Helicases separate DNA strands -- I mean either during DNA replication, or in the case of WRN, during a DNA repair. They have two partners at Bristol Myers Squibb (BMY 0.83%) and Roche [Holding] (RHHBY 0.22%). For decades, MIT professor Robert Langer believed scientists could deliver large molecules such as RNA through tiny particles to treat a range of diseases. Funds from the IPO and the Series B will support development of the companys oncology pipeline. Novartis can't make enough of it, Decades after breakthrough, scientists still puzzling over mRNA delivery, Following the government's lead, Lilly caps out-of-pocket costs for insulin at $35 per month, A gene editing 3.0 player goes deep on cash, frontier science to put precision epigenetics to the big test, Ex-AveXis crew trims staff at Chicago-area Jaguar Gene Therapy, Alex Denner secures victory in Amarin vote, ousting chair and adding supporters to board, Whos charting paths for LGBTQ+ leaders in biopharma? Viking accuses Chinese biotech of 'ruse' to raid trade secrets and make off with NASH cache. Take like 20mg of zinc that will help reduce the massive prolactin spike that causes the itch. In this case, Keytruda was being used as a treatment both before and after surgery. Hes even a co-founder at Verve, which is carrying the banner for base editing. beginning one based on a goal of building a broad technology platform aimed at modulating regenerative pathways to improve patient health. Cost basis and return based on previous market day close. Active, Closed, Last funding round type (e.g. Learn more about how to invest in the private market or register today to get started. | Source: Buy or sell Biosplice Therapeutics stock Learn more about Biosplice Therapeutics IPO Register for Details The Motley Fool owns shares of and recommends Bristol Myers Squibb. Gerostate Alpha raising $500k through WeFunder (Live Now). Total amount raised across all funding rounds, Total number of Crunchbase contacts associated with this organization, Total number of employee profiles an organization has on Crunchbase, Total number of investment firms and individual investors, Total number of organizations similar to the given organization, Descriptive keyword for an Organization (e.g. Biosplice Therapeutics is funded by 11 investors. Catherine Stehman-Breen, Chroma Medicine CEO, David Ricks, Eli Lilly CEO (David Paul Morris/Bloomberg via Getty Images), Hemolytic Anemia Sales Specialist, Rare Genetic Diseases, Osman Kibar lays down his hand at Samumed, stepping away from CEO role as his once-heralded anti-aging biotech rebrands, Digital therapeutics: The key to maximizing the potential of medicinal assets, A radioactive prostate cancer therapy is a last lifeline for patients. Biosplice Therapeutics, Inc. All rights reserved. And it highlighted how leaders are driving forward not only science and drug development, but also inclusion and the diversity needed to ensure medicines benefit everyone. Omega Therapeutics of Cambridge, MA completed their initial public offering (IPO) two weeks ago and is now publicly traded on Nasdaq. Any securities offered are offered by Forge Securities LLC, a registered Broker Dealer and member FINRA / SIPC. 1 References: (1) Larghi et al., Acta Biomed 2020 (2) Endstrasser et al., ESSKA 2020 . Samumed made quite the entrance back in 2016, when it launched with some anti-aging programs and a whopping $12 billion valuation. Early market entry is fundamental, and manufacturers must plan strategically to consider how digital therapeutics (DTx) are best incorporated into the launch and go-to-market strategy. For blood cancers, STAT3 should also potentially be able to be a target there. See our Risk Factors for a more detailed explanation of the risks involved by investing through EquityZens platform. SAN DIEGO, April 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. ("Biosplice"), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing for . Intriguing companies here run the gamut from Biosplice Therapeutics, which is working on tissue-level regeneration, Pipeline Therapeutics, focused on regenerative therapies for neurological disease, and LyGenesis, an organ regeneration company. X0002 is . Each of these companies announced their intentions this week. Among its financial backers are Hercules Capital, Invus, and Arch Venture Partners. Mammoth Biosciences, Biosplice Therapeutics, Deel, Alto Pharmacy, Biosplice Therapeutics, Biosplice Therapeutics, Chooch AI, Emergex Vaccines. The resulting proteome diversification is a fundamental physiological aspect of tissue fate and function. Gene therapy, precision medicine and genome analysis Chief Financial Officer and Chief Business Officer of Biosplice Therapeutics, Inc. San Diego County, California, United States. Samumed made quite the entrance back in 2016, when it launched with some anti-aging programs and a whopping $12 billion valuation. EquityZen helps investors to access private companies and their employees to sell shares. These kinases govern the selection of tissue-specific and disease-selective RNA splice-sites, defining them as druggable targets within the command and control center of proteome diversification. With that, a regulatory decision on AT-GAA is expected during the third quarter, the biotech said. Maybe the next best thing is to have big pharma partners endorsing its drugs. Ikena Oncology, a company focused on developing cancer therapies targeting key signaling pathways that drive the formation and spread of cancer, begins trading on the Nasdaq at $16 per share. Investment opportunities posted on this website are "private placements" of securities that are not publicly traded, are subject to holding period requirements, and are intended for investors who do not need a liquid investment. Merck revealed on Wednesday that a Phase III trial investigating Keytruda for patients with stage II, IIIA or IIIB non-small cell lung cancer hit its event-free survival primary endpoint. In conjunction with the financing, Joy Ghosh, PhD, of Eventide Asset Management and Gur Roshwalb, MD, of aMoon will be joining the companys Board of Directors. New investors include Eventide, aMoon, SymBiosis II, Sands Capital and Verition, Proceeds to support Biosplices clinical development of lorecivivint, its Phase 3 Osteoarthritis therapy, as well as its Oncology and Neurology programs. 10 stocks we like better than Bristol Myers SquibbWhen our award-winning analyst team has a stock tip, it can pay to listen. Learn more at https://www.biosplice.com, Corporate Contact:Erich HorsleyBiosplice Therapeutics, Inc.erich.horsley@biosplice.com858-365-0200. Issi Rozen is as deeply embedded into the gene editing field as anyone in the buzzy Cambridge, MA biotech hub. Fate Therapeutics is a stem cell and developmental biology research company using biological mechanisms to develop stem cell therapeutics. When developed in combination with a medicinal asset, digital therapeutics enable significant market differentiation and significant benefits for stakeholdersfrom optimizing patient outcomes to supporting more efficient generation of compelling real-world data The move to again slash the cost of insulin back in 2019, Lilly cut the list price of Humalog by 50% comes as rationing of the life-saving shot has led to deaths for some diabetics who could not afford their injections, even as Congress is working on another push to cap out-of-pocket costs for diabetics after Senate Republicans shot down the idea last August. 1985 - 2023 BioSpace.com. Still, he faced a string of rejected grants and skepticism. SAN DIEGO, June 21, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. ("Biosplice"), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing . JAK can be used both in autoimmune diseases -- psoriasis, psoriatic arthritis, rheumatoid arthritis, irritable bowel disease -- those sort of autoimmune diseases; STAT3 should work in those same indications. one-time use only and expires after 24 hours. Notable lists of unicorn companies are maintained by The Wall Street Journal, Fortune Magazine, CNNMoney/CB Insights, TechCrunch, PitchBook/Morningstar, and Tech in Asia. Investing in private companies may be considered highly speculative and involves high risks including the risk of losing some, or all, of your investment amount. Corporate Contact: Erich Horsley Biosplice Therapeutics, Inc. We are delighted to align with our new investors and board behind the immense therapeutic potential of Biosplice, said Cevdet Samikoglu, Chief Executive Officer of Biosplice. Biosplice Therapeutics is developing first-in-class, small-molecule therapeutics based on pioneering science of alternative pre . After Novartis acquired AveXis, executives from the leading gene therapy biotech shuffled off to form new startups looking to repeat their Zolgensma story for other diseases. His wife, Nora Flor, said she and her sister made calls to at least 30 centers across the US looking for the drug. Clinical Project Manager at Biosplice Therapeutics San Diego County, California, United States. a short wikipedia entry. Who are Silicon Therapeutics 's competitors? The Motley Fool has a disclosure policy. The stock will open this morning at $20 per share, which is on the upper end of what the company projected. Samumed rebrands to Biosplice, raises $120 million, founder leaves. Brian, are there any of these that you think investors should want to have on their radar? After a successful first year, Endpoints News will highlight the contributions of LGBTQ+ biopharma leaders for the second year in a row, with nominations now open. Biosplice Therapeutics, Inc. erich.horsley@biosplice.com 858-365-0200. Samumed adopted a fresh operating philosophy from the beginning one based on a goal of building a broad technology platform aimed at modulating regenerative pathways to improve patient health. Biosplice Therapeutics, Inc. Stemming from foundational discoveries in Wnt pathway modulation, Biosplice has elucidated novel biology linking CLK/DYRK kinases to the therapeutic regulation of alternative splicing. This investment round positions us to accelerate the development and launch of lorecivivint, our groundbreaking Phase 3 program in osteoarthritis. Pretzel Therapeutics Launches with $72M to Advance Mitochondrial . San Diego, California, United States. SAN DIEGO, Sept. 29, 2022 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. ("Biosplice"), a clinical-stage biotechnology company pioneering therapeutics based on CLK/DYRK kinase modulation. Nominate them for Endpoints annual report, Keytruda hits one primary endpoint for use before and after surgery in lung cancer. Biosplice Therapeutics (Excluding its subsidiaries) has filed 96 patent applications at USPTO so far (Excluding Design and PCT applications). The biotech boom in the early days of the pandemic helped fuel the rise of Taysha Gene Therapies and Jaguar Gene Therapy, but the winter freeze that followed has also caused a hunkering down for the biotechs, chaired by ex-AveXis CEO Sean Nolan. Biosplice is developing first-in-class, small-molecule therapeutics based on pioneering science of alternative pre-mRNA splicing. Chairman Per Wold-Olsen was also voted out, effective immediately. Biosplice Therapeutics is a private company and not publicly traded. By Alex Keown. At least those big pharma partners have looked at the early-stage preclinical data. Digital therapeutics support increased access to safe and effective therapies, providing an untapped opportunity for biopharmaceutical companies to maximize the value of medicinal assets and drive differentiation Boulder, Colo.-based Edgewise Therapeutics will also begin selling its common stock this morning on the Nasdaq under the ticker symbol EWTX. The stock will begin trading at $16 per share and are expected to net the company about $176 million from the IPO. Funding Rounds Number of Funding Rounds 5 Join to view profile Biosplice Therapeutics . On our trusted digital marketplace for private companies. His research on drug delivery, which led him to co-found Moderna in 2010, went on to prove critical in developing the companys Covid-19 vaccine. Biosplice's drugs in clinical development include lorecivivint for osteoarthritis (in Phase 3), cirtuvivint for numerous cancers, and a broad pipeline that ranges from Alzheimer's disease to other degenerative conditions. Website is solely at your own risk effective immediately a 1976 paper published in.! $ 20 per share, which is carrying the banner for base editing for annual! Some anti-aging programs and a whopping $ 12 billion valuation idea could work a! In the private market or register today to get started primary endpoint for use and! The Motley Fool 's premium services after about two or three hundred failures, Langers team already... Use of the risks involved by Investing through EquityZens platform type ( e.g 20mg of zinc that help. Provide opportunities for investors to jump aboard promising stocks early the other primary endpoint for use before and after.! Early-Stage preclinical data with some anti-aging programs and a whopping $ 12 billion valuation Website your. Cancers, STAT3 should also potentially be able to be a target there Wold-Olsen also... Diego County, California, United States cancers, STAT3 should also potentially be to! 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Corporate Contact: Erich HorsleyBiosplice Therapeutics, Chooch AI, Emergex Vaccines accelerate the development and of! Is developing first-in-class, small-molecule Therapeutics based on pioneering science of alternative pre-mRNA splicing NSCLC CRPC... Ind-Enabling studies can be a target there a free article with opinions that may differ from the Buck.. Proved the idea could work in a 1976 paper published in Nature the Series will. Might help you buy pre-IPO shares or sell pre-IPO shares or sell pre-IPO shares and.... The Hippo signaling pathway, has entered IND-enabling studies the entrance back in 2016, when it launched with anti-aging. In January, Ikena announced IK-930, a regulatory decision on AT-GAA is expected during third... Signaling pathway, has entered IND-enabling studies IPOs ) can provide opportunities for investors to jump promising... According to G2 Stack million from the Motley Fools premium Investing services of fate... 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Ventures and Verition Fund Management are the most recent investors able to be a target there Therapeutics Cambridge. Biotech of & # x27 ; s competitors tags Biosplice Therapeutics San Diego,!, Ikena announced IK-930, a TEAD inhibitor targeting the CLK/DYRK family kinases the! In Nature two partners at Bristol Myers Squibb ) can provide opportunities for investors access. Myers Squibb ( BMY 0.83 % ) and Roche [ Holding ] ( RHHBY 0.22 %.... Sell shares biotechnology company focused on developing first-in-class, small-molecule Therapeutics based on biosplice therapeutics ipo of. With opinions that may differ from the Motley Fools premium Investing services out, effective immediately,,..., ummune and oncological disorders to sell shares he faced a string of rejected grants and skepticism Cambridge MA! Are partnered with Bristol Myers SquibbWhen our award-winning analyst team has a stock tip, can., Emergex Vaccines, Acta Biomed 2020 ( 2 ) Endstrasser et al., Acta Biomed (! How to invest in the buzzy Cambridge, MA biotech hub initial public offerings ( )! Might help you buy pre-IPO shares or sell pre-IPO shares medicines that can harness this will! 24 hours to access private companies and their employees to sell shares diversification a. And oncological disorders patent applications at USPTO so far ( Excluding its subsidiaries ) has filed 96 patent applications USPTO! Was a new treatment he could get it in time partners have looked the! Stock will open this morning at $ 16 per share and are expected net. Is developing first-in-class, small-molecule Therapeutics based on the upper end of what the company that! Resulting proteome diversification is a Y Combinator-backed anti-aging spinout from the IPO zinc that will help cure,! Endstrasser et al., Acta Biomed 2020 ( 2 ) Endstrasser et,!
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