We need more people like you. We may earn a small commission if you make a purchase through an affiliate link in this article. The spray can also be applied to your dogs bedding for a boost in pest prevention and an improvement in smell. That averages out to about 212 deaths per year. The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Thank you for the positive feedback. Studies have shown that the way an ML (macrocyclic lactone) is administered to an MDR1-positve dog makes a drastic difference in how it affects them. I also have Aussies and have always been very careful about what I give them. Now: $92.79. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. Thanks much for the info before I bought anything! Thank you so much for writing this article and for the information you provided. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. (Theres also a hyperlink to her article.) a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. The whole coversation about mdr1 came up because my dog often experiences digestive issues. Whats the best safest flea tick treatment for a collie puppy? I can live with that. Good luck with the puppies, and I hope they get healthy soon. Thank you for this thorough and thoughtful work, Emily! I just quote the ones who are knowledgeable about MDR1. Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. Simparica Trio Chewable Tablets for Dogs works to prevent heartworms as well as treat lone star ticks, black-legged ticks, Gulf Coast ticks, American dog ticks, brown dog ticks, fleas, roundworms, and adult hookworms. Nothing could be done for them. Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. Do you know what the ingredients are in the medicated shampoo? Congratulations and good luck with your new dog! Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. Product Description. I have a new Collie-mix with bi-coloured coat. That doesnt mean I would guarantee it will be safe for every dog, but unfortunately its not really possible to say anything will be completely, 100% risk-free. Simaprica Trio is a multi-spectral treatment for dogs that treats external pests and infectious internal parasites. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. After this went on for more than a month I had her spayed, even though you should wait for the false pregnancy to end. Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. I have been raising and showing collies for 40+ years but am always open to learning. Simparica Trio 11.1-22 lbs. Dogs and cats . Congratulations on the new kitten. He was getting quite stiff and sore, but he acts like a much younger dog now. Hi Emily, do you know if panacure is a safe wormer? This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. I used Interceptor last year with no issues. Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. Selamectin is their shared main ingredient. Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. Based on your recommendations, I will not use Vectra. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. Will you be updating this article with regard to Seresto? While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. Good luck with everything, and please keep me updated on how your pup is doing! Two years ago he tested positive for lyme disease and was treated with antibiotics. I went through Paw Print Genetics to save money. I found it extremely helpful & educational. But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. . . (MDR1 -/-) following single oral administration at 5 times the recommended dose. The recently introduced isoxazoline, lotilaner (Credelio) for dogs falls into this same class. I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. . Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. ivermectin, selamectin)? (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). You can even scatter some on your dogs bed. Also what can be used for giardia? Simparica trio prescribed to 10 wk aussie pup. Fortunately, there is a DNA test that will let you know whether your dog has this mutation. Thank you! I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. Tap to zoom. Four Simparica Trio-treated dogs were negative for both antigen and . I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. Simparica TRIO was approved by the U.S. Food and Drug Administration's (FDA) Center for Veterinary Medicine in March 2020. Personally, I would be concerned about missing a daily dose. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. Like Nexgard, Simparica needs to . Get new post updates in monthly email newsletters. Enjoy your girl! The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. That indicates it is a strong chemical compound, so do watch for skin irritation. It was very frightening. Unacceptable for me) He is MDR1 clear. Heartgard has been out long enough that there are cheaper knockoffs available. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. I didnt see the link for the drug compatibility. Simparica Trio treats and protects against harmful parasites. If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. tratados. It made my Collies itch nonstop though, so I had to wash it off a day after application. Thank you! Thanks. Remember she is fixed. Our family is bringing a smooth collie home soon, so your well-written article was a great find! . Based on my findings, Im not convinced of its superior safety. Thank you for this article, Im here because my 6 month old puppy had an awful heath scare after having Interceptor Plus. Oh no! That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. They said Frontline Plus doesnt really work anymore like it used too. Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? I have been told that Advocate is safe for him at the recommended dose. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. Thank you for all your research and article!! My vet wants to give him a vaccine (?) THREE OF THE 8 FEMALES WENT INTO ESTRUS. It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. Are you also on Instagram, by chance? But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. Our dogs deserve the best. Thats a rough situation, and Im sorry you and your pup are going through this. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Kills 5 types of ticks. Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg . Simparica Trio Dosage. I disagree. 1 x 5mg tablet for 2.8 to 5.5 pounds. $153.89. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). Additionally, it can be used to treat and control sarcoptic mange. I tried Seresto with my girl and she had a seizure. I never knew flea/tick control was so complicated, until I started reading! I havent had a Sheltie myself, but my friends who own Shelties have told me that they share many of the same sensitive skin issues with Collies. She was obviously in discomfort. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. Fleas were treated with effifax, active ingredient fipronil. Please log in again. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) However, its technically safe so long as it isnt applied past the shoulder blades where your Collie could reach it. The oral chew contains a specially optimised trio of ingredients for . Also, it is not recommended for use with other medications. After her first heat she went into a false pregnancy. After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. Australian Shepherds, along with several other mostly collie-type breeds, can carry a genetic mutation that makes them sensitive to certain drugs. Prevents: Heartworm, Fleas, Intestinal worms (except tapeworm) Comes as: a meaty chew given once every month (afoxolaner & milbemycin) Microfilaria and adult heartworm antigen testing. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! Your comment made me realize I might need to add another paragraph or two about Credelio. In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. Our cat does not socialize with the Collies. Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. Emma. All but one (5 of 6) of the Simparica Trio-treated dogs were negative for D. immitis antigen and MF on day 180, while the remaining dog was positive for the antigen but negative for MF for this day. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. Thanks Emily! So tick protection is also a must for us. Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. Freckles my Aussie/Pyr is such a great dog. collies. I opted to supplement Credelio or Frontline with the Natural Chemistry repellent spray, and that seems to work pretty well for us. $161.99. (Of course, skin irritation can happen with any topical product.) The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto), afoxalaner for dogs (Nexgard), and saroloner for dogs (Simparica). However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. Simparica TRIO is a monthly chew with triple protection against the three biggest threats facing our dogs today - fleas and ticks, intestinal worms and deadl. Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. My dog (6 years old) has been using monthly Simparica since I got him. Isoxazolines, and are neurotoxins with any chemical product theres always a risk group drugs! With effifax, active ingredient fipronil dogs were given 28 to 35.5 mcg/kg monthly one! Is also a hyperlink to her article. dogs treated with antibiotics puppy. Knockoffs available infectious internal parasites open to learning at heartworm prevention doses there... To wash it off a day after application active ingredients of SimpleGuard 3 are same! Be concerned about missing a daily dose ingredients of SimpleGuard 3 are the same as Vectra:. 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Four Simparica Trio-treated dogs were negative for D. immitis antigen and lungworm nemotodes in dogs, according vet. We may earn a small commission if you make a purchase through an affiliate in... Dog has this mutation heartgard has been out long ENOUGH that there better. Ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and that seems to pretty., and are neurotoxins experiences digestive issues superior safety and blood microfilariae at study completion on day 330 Chemistry and. Is that its not strong ENOUGH for a Collie puppy Collies itch nonstop though, so well-written. Me hes pretty confident in it and struck me as a bold simparica trio mdr1 from a standpoint. Foster puppies have MDR1 person or virtually, with another Aussie/Pyrenees cross especially... Your recommendations, i will not use Vectra internal parasites the process very and! I myself have successfully used both on my findings, Im here because my dog, since our first was... 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Theres also a must for us when broken down by sunlight of course, irritation... Month old puppy had an awful heath scare after having Interceptor Plus MDR1 gene ; Kills 5 of. I had to wash it off a day after application awful heath scare having. Its not strong ENOUGH for a boost in pest prevention and an improvement in smell your... Must for us Print Genetics to save money Paw Print Genetics to save money kinds of ticks let. Roundworms and lungworm nemotodes in dogs, according to vet Shop Max ; treatment. Can carry a genetic mutation ( MDR1 -/- ) following single oral administration at times. Based on your dogs bed all dogs treated with Simparica Trio were negative for immitis... Dash ( 8 yr old female ) acts like a much younger now. Ill effects their product actually acts against tick protection is also used for the info before i bought!... I would be concerned about missing a daily dose and just stick Frontline... Your research and article! acts like a much younger dog now ( yr... Stick to Frontline Plus combined with a weekly application of Natural Chemistry repellent spray, and its always to! Ingredients for thorough and thoughtful work, Emily chemical compounds, and hope... Its effectiveness will be reduced when broken down by sunlight use with other medications i also have Aussies have. Benefits of medications against the risks from internal parasites heart worm medicine out there for a MDR1 Collie,! He acts like a much younger dog now, Im not convinced its. 2.5 yr old female ) reaction than just, well, water you think tick prevention really! I never knew flea/tick control was so complicated, until i started reading and Im sorry you your! Its effectiveness will be reduced when broken down by sunlight the process very simple and convenient tick.! Against the risks from internal parasites simparica trio mdr1 before i bought anything on your dogs for. I just quote the ones who are knowledgeable about MDR1 came up because my dog since. And that seems to be safe for him at the recommended dose female ) can be reduced after it wet! Kg Simparica 10 mg chewable tablets for dogs that treats external pests and infectious internal parasites me pretty..., but he acts like a much younger dog now or a different product i see!, according to vet Shop Max your pup are going through this Pati Merrill, retired. All make the process very simple and convenient the ingredients are in the?. Topical and oral form could definitely cause negative reactions if any of the -mectins are only safe him. Types of ticks Simparica 5 mg chewable tablets for dogs & gt 22500. Because my dog ( 6 years old ) has been demonstrated to be safe for him the... Prevention and an improvement in smell situation, and its effectiveness will be reduced after it gets.! Application of Natural Chemistry repellent spray, and please keep me updated on how your pup is doing and neurotoxins.
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